Given ZFP423’s role as a transcriptional coactivator of PPARG2 mRNA expression in determining preadipocyte commitment to adipogenesis in normal adipose tissue [14] and the impact of ZFP423 depletion or overexpression on adipogenic potential in the liposarcoma cells lines, these results suggest the difference in adipogenic capacity of the well-differentiated or dedifferentiated liposarcomas occurs at preadipocyte commitment. The gene discussed is ZNF423; the disease is liposarcoma.