The results revealed that high CISD1 expression was significantly associated with poor OS of ACC (HR: 1.03 (1.01−1.04), p = 0.00450), BLCA (HR: 1.01 (1–1.02), p = 0.03), BRCA (HR: 1.01 (1–1.02), p = 0.0053), LAML (HR: 1.1 (1.02−1.18), p = 0.011), LIHC (HR: 1.02 (1.01−1.03), p = 0.00016), LUAD (HR: 1.02 (1.01−1.03), p = 0.0011), and THYM (HR: 1.04 (1.01−1.07), p = 0.0014), but with better OS in LGG (HR: 0.98 (0.96−0.99), p = 0.00170) (Figures 2(a)–2(i)). Here, CISD1 is linked to adrenal cortex carcinoma.