CISD1 and hepatocellular carcinoma: In addition, high expression of CISD1 was associated with worse OS in Asian HCC patients (OS HR = 1.87 (1.03-3.38), p = 0.035), stage I and II HCC patients (OS HR = 1.64 (1.02-2.67), p = 0.047), and patients with hepatitis virus-positive (OS HR = 2.12 (1.11-4.05), p = 0.019) (Table 1).