Related studies have shown that the levels of CD3+, CD4+, and CD8+ in peripheral hematoma of patients with condyloma acuminatum in the anal canal are significantly lower than those without recurrence, indicating that there is a significant correlation between the recurrence rate of patients with condyloma acuminatum in the anal canal and their own immune level [27]. The gene discussed is CD8A; the disease is anogenital human papillomavirus infection.