2007), and nidogen (I79_015301) is known to interconnect the laminin (Lama) and collagen networks with the assistance of perlecan (Hspg2) to help form a rigid basement membrane (Singh et al. 2012). Finally, the biological connection of the members of the last cluster encompassed only three proteins—amyloid-beta A4 protein (App), clusterin (Clu), and an early endosome antigen (Eea1) protein that is known predominantly from Alzheimer’s disease research (Wojtas et al. 2017, 2020; Zhao et al. 2021). Here, HSPG2 is linked to early-onset autosomal dominant Alzheimer disease.