Interestingly, however, Svep1 is evolutionarily highly conserved, and genotyping efforts by the Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia identified missense variants in Svep1 associated with coronary artery disease and elevated blood pressure (Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, 2016). The gene discussed is SVEP1; the disease is coronary artery disorder.