PLCZ1 and hyperinsulinemic hypoglycemia, familial, 4: While we pursue further research, it is important that we educate patients, via online forums, webinars, or awareness events, so that they fully understand the relationship between OAD and PLCZ1 and our current ability to diagnose PLCZ1 deficiency but are also aware of our current diagnostic and therapeutic limitations and the lack of evidence-based data relating to the widespread application of AOAs.