PLCZ1 and Globozoospermia: Subsequent studies showed that patients diagnosed with partial or complete globozoospermia are unable to fertilize oocytes naturally and that this deficiency is related to reduced levels or the total absence of PLCZ1 (Taylor et al. 2010, Abadi et al. 2016, Tavalaee & Nasr-Esfahani 2016, Tavalaee et al. 2018, Cheung et al. 2020).