GPX4 and cancer: Ferroptosis can be triggered by small molecules thattarget the system Xc inhibitor, erastin, or RSL3, a GPX4 inhibitor.45 Interest in ferroptosis has increased as recentstudies have shown that ferroptosis inducers may enhance the chemosensitivityof drug-resistant cancer cells toward chemotherapeutic drugs.45,46 Ferroptosis-based cancer therapies are expected to overcome thelimitations of current traditional therapeutics due to resistanceto apoptosis or necrosis.