NFKB1 and osteosarcoma: The triterpenoid celastrol (compound 32, Figure 1) has been recently shown to inhibit Ang II-induced cardiac dysfunctionby inhibiting STAT3 activity in in vitro and in vivo models.30 Furthermore,at low concentrations, compound 35 inhibited the migrationand invasion of osteosarcoma cells by suppressing MMP-2/9 expression,which is also dependent on NF-κB transcription.