Although previous studies have shown that OPN promotes progenitor cell expansion and tumorigenicity via activation of β‐catenin (Lin et al., 2020), and that β‐catenin could be a transcriptional coactivator for OPN expression in cancer (Yang et al., 2017), the relationship between β‐catenin and OPN in renal fibrosis is unclear. This evidence concerns the gene SPP1 and renal fibrosis.