There are limited studies examining the response of UCP1 to exercise training in human adipose tissue and most studies have looked at gene expression data, which have found that UCP1 in scWAT either decreases (Brandao et al., 2019), does not change (Norheim et al., 2014; Pino et al., 2016), or increases (Norheim et al., 2014; Otero‐Díaz et al., 2018) if groups (controls vs. patients with pre‐diabetes are collapsed). Here, UCP1 is linked to diabetes mellitus.