However, our results show that viral infection or genetic knockout of lincRNA‐EPS facilitates PKR‐STAT1 signaling axis induced antiviral genes such as Mx1, Oas2, Ifit2, and Irf7, while inhibits phosphorylation of TBK1 and IRF3, as well as the IFN‐β induction. The gene discussed is IFIT2; the disease is viral infectious disease.