IFNAR1 and systemic lupus erythematosus: However, overproduction of IFN‐I and hyperactivation of IFN‐α/β receptor (IFNAR) downstream signaling lead to autoimmune diseases including systemic lupus erythematosus (SLE) and Aicardi‐Goutières syndrome (AGS) (Chaussabel et al, 2008; Crow & Manel, 2015).