PRKN and Parkinson disease: Furthermore, autosomal dominant PD can result from variably penetrant mutations in genes linked to mitochondrial form and function, such as LRRK2 (involved in basal and PINK1/Parkin mitophagy, mitochondrial trafficking and electron transport chain) [17,18], SNCA (mitochondrial morphology and biogenesis; encodes for α-synuclein, the major component of Lewy bodies- a primary pathology of PD), VPS35 (mitochondrial fission and fusion) and CHCHD2 (mitochondrial function and biogenesis) [16].