PRKN and Parkinson disease: In particular, mutations in LRRK2 (G2019S and R1441C), which constitute the most common monogenic cause of PD, lead to impaired accumulation of its substrate Rab10 on depolarised mitochondria and diminish PINK1/Parkin dependent mitophagy [17], highlighting a potential general role for mitophagy in pathobiology of PD.