Thus, adult-onset loss of TDP-43 function in oligodendrocytes, which may occur in disease and injury states (Wiesner et al., 2018; Sun et al., 2017), triggers phenotypes commonly observed in mouse models of ALS, Parkinson’s disease (PD), and MS (Wong and Martin, 2010; Lieu et al., 2013; Gharagozloo et al., 2021). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.