Although neurons have been the primary focus of research into TDP-43-associated pathologies, nuclear exclusion, and cytoplasmic aggregation of TDP-43 also occur in glial cells in neurodegenerative diseases, such as MS (Neumann et al., 2006; Masaki et al., 2020; Rohan et al., 2014), suggesting that glial cell dysfunction could impair both OPC homeostasis and remyelination. This evidence concerns the gene TARDBP and myeloid sarcoma.