USP16 and Cognitive impairment: (C) Novel object recognition 24 hr testing in mice at 6 months of age showed the earliest signs of cognitive impairment in the Tg-SwDI mice with a preference index (PI) of 49%, while WT and Tg-SwDI/Usp16+/- mice had PIs >65% indicating intact object discrimination (p=0.001 for WT and p=0.0099 for Tg-SwDI/Usp16+/-, n = 7–10 mice).