In this investigation, it was observed that MAP3K1, MAP3K3, MAP3K5, MAP3K10, and MAP3K15 were upregulated in HCC tumor tissues, whereas MAP3K7, MAP3K8, MAP3K9, and MAP3K11 were downregulated in tumor tissues in GSE14520. The gene discussed is MAP3K15; the disease is hepatocellular carcinoma.