Gender (P = 0.021), cirrhosis (P = 0.036), and BCLC stage (P < 0.001) were associated with the RFS of HBV-related HCC, and the AFP level (P = 0.049), BCLC stage (P < 0.001), cirrhosis (P = 0.041), and tumor size (P = 0.002) were independent predictors for OS (Table S1). The gene discussed is AFP; the disease is neoplasm.