The top keywords were “ampk,” “activated protein-kinase,” “expression,” “autophagy,” “oxidative stress,” “apoptosis,” “metabolism,” “activation,” “phosphorylation,” “metformin,” “insulin-resistance,” “inhibition,” “inflammation,” “obesity,” “skeletal-muscle,” “protein-kinase,” “cells,” “pathway,” “growth,” “gene-expression.” Therefore, research hotspots can be summarized in the following aspect. The gene discussed is WEE1; the disease is obesity disorder.