In T2DM with HOMA-IR >2.8 subgroup, such association was also presented between adiponectin and HDL-C: (R = 0.3591, P = 0.0195) or HDL-C/LDL-C (R = 0.3327, P = 0.0313). The gene discussed is ADIPOQ; the disease is type 2 diabetes mellitus.