Fourthly, a follow-up study should be conducted and focused on the variations of adiponectin, nesfatin-1, IL-6, and TNF-α in prediabetes patients with medical therapy such as metformin or other antidiabetic drugs, which may be helpful to illustrate the roles of these factors in the development of prediabetes as well as for early diagnosis and intervention of the disease. The gene discussed is TNF; the disease is prediabetes syndrome.