The pooled results revealed that overexpression of LOX and LOXL4 were associated with worse OS of LC patients (HR: 1.59, 95% CI: 1.19-2.12, I2 =0%; HR: 1.58, 95% CI: 1.28-1.96, I2 =0%), while the association between overexpression of LOXL2 and OS of LC patients showed no statistical significance (HR: 1.33, 95% CI: 0.99-1.79, I2 =29.5%) (Figure 13). Here, LOXL4 is linked to laryngotracheoesophageal cleft.