MTOR and cancer: In the present study, we intend to characterize biological effect of ZDQ-0620 in CRC cells, including cell proliferation, migration, invasion and angiogenesis, and further clarify the underlying mechanisms through modulating the PI3K/AKT/mTOR pathway, which sheds a light upon the thought of developing PI3K inhibitor and provides a promising direction as an anti-cancer drug against CRC in future.