Previous studies conducted by our team have shown that FTO-mediated m6A modification plays an important role in hepatocellular carcinoma, and the SIRT1 deacetylase can play a carcinogenic role by down-regulating FTO. FTO is an RNA demethylase that can remove the methylation of m6A in mRNA both in vitro and in vivo (59, 60). Here, FTO is linked to hepatocellular carcinoma.