CXCR4 and melanoma: confirmed that the deletion of YTHDF1 enhances the therapeutic effect of the PD-L1 checkpoint blockade (19).In melanoma, elevated FTO expression levels promote tumor growth by reducing the methylatin of m6A in the mRNA for PD-1 (PDCD1), CXCR4, and SOX10 and preventing their RNA decay mediated by YTHDF2.