We also analyzed the differences in the expression of genes in important biological pathways for bladder cancer (51), including the FGFR3 gene signature; CD8 Teff signature; antigen-processing machinery; immune checkpoint signature; MKI67 and cell cycle genes; DNA replication-dependent histones; DNA damage-repair genes; TGFβ receptor and ligand; F-TBRS genes; EMT markers; and the angiogenesis signature. The gene discussed is CD8A; the disease is urinary bladder cancer.