CXCR4 and melanoma: Further, the authors showed that an FTO knockout can increase m6A methylation in key oncogenic melanoma cells, including the loci for PD-1 (PDCD1), CXCR4, and SOX10. The inhibition of FTO makes melanoma cells sensitive to interferon-γ (IFN-γ) and anti-PD-1 therapy in mice, indicating that FTO plays an important role in promoting the occurrence of melanoma and anti-PD-1 drug resistance.