It was also found that the expression level of PRMT6 in GC was significantly higher than that in non-cancer tissues, and overexpression of PRMT6 enhanced the aggressiveness of gastric cancer cells and increased the expression level of H3R2me2a in GC cells through the direct pathway of transcriptional inhibition of tumor suppressor gene procadherin 7 (PCDH7), and the expression level of H3R2me2a was an independent prognostic indicator of GC. Here, PRMT6 is linked to cancer.