RB1 and acute myeloid leukemia: It has also been found that increased activity of PRMT5 promoted the growth of AML in vitro and in vivo, while downregulation of PRMT5 decreased the growth of AML (102), and elevated levels of PRMT5 in some leukemia and lymphoma cells lead to H3R8 and H4R3 hypermethylation and transcriptional silencing in promoter regions of the RB tumor suppressor family, which suggest that PRMTs can regulate the expression of miRNAs (103).