GSTP1 can detoxify several anticancer drugs and mediate specific S-glutathionylation of ER-resident proteins to induce chemotherapy resistance in tumors and stress response, suggesting that the decrease of PRMT6 expression and subsequent increase of G6PD expression give ovarian cancer cells resistance to paclitaxel by regulating GSTP1 expression. The gene discussed is PRMT6; the disease is ovarian carcinoma.