However, early endocrinological consultation is advisable following the onset of polyuria, not only when the diagnosis is uncertain, but also to define whether ICI-induced CDI is more likely due to panhypophysitis (e.g., anti-CTLA4 mAbs) or isolated damage to the posterior pituitary or the hypothalamus (e.g., anti-PD1/PD-1L mAbs). The gene discussed is CTLA4; the disease is clostridium difficile infection.