There are two forms of B7H6—cell-surface B7H6 and soluble B7H6 (sB7H6)—and both have been detected in primary tumors and the tumor microenvironment, including in glioma, neuroblastoma, breast cancer, non-small cell lung cancer, hepatocellular carcinoma, gastric carcinoma, ovarian cancer, leukemia, and lymphoma—though rarely in normal tissues (14–22). The gene discussed is NCR3LG1; the disease is breast cancer.