EGFR and non-small cell lung carcinoma: A recent analysis of a prospective registry of 218 patients with NSCLC EGFR-mutated (EGFRm) and EGFR-wild-type brain metastases treated with SRS plus or minus systemic therapies, did not show a statistically significant difference in local failure or radionecrosis rate at 24 months in EGFRm patients with administration of tyrosine kinase inhibitor before SRS (3% and 3%) or after SRS (17% and 0%).