of 174 NSCLC brain metastases patients treated with SRS within 3 months of receiving systemic therapies found significantly improved distant intracranial control with EGFR-TKI therapy compared to conventional chemotherapy (HR 0.4; 95% CI 0.25-0.76; P = 0.04) and with receiving SRS before systemic therapy (HR 0.6; 95% CI 0.3-0.9; P = 0.03) (28). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.