• LC rates at 12 and 18 months were 97% and 90%, respectively• Median OS from the first sf-GKRS was 15.7months• Low serum albumin (HR for death 5.3), corticosteroid use pre-sf-GKRS (HR for death 5.8) and KPS < 80 (HR for death 9.1) were independently associated with worse OS• Adverse radiation effects (ARE) were seldom symptomatic and were associated with tumor volume, 10- Gy volume and pre-treatment perifocal edema• ARE were less common among patients treated with TA within 1 month of sf- GKRS. Here, ALB is linked to neoplasm.