Melanoma cells overexpressing mutant HSF1 with a deletion in the transcriptional activation domain were resistant to doxorubicin and paclitaxel (but not cisplatin, bortezomib and vinblastine), correlating with overexpression of several ABC transporters (ABCB1, ABCB8, ABCC1, ABCC2, ABCC5 and ABCD1) and increased drug efflux (226). The gene discussed is HSF1; the disease is melanoma.