In contrast to typical CTCs and CTECs, a large amount of CRC subtypes have tumor biomarkers, CD31 and Vimentin expressed in pair with abnormal multiple chromosomes (Figures 3A–C); another subtype of diploid CRC with CK18/CD31/Vimentin-positive staining simultaneously was also observed in this study (Figure 3D). Here, KRT18 is linked to neoplasm.