PECAM1 and cancer: Furthermore, the rarely reported aneuploid mesenchymal (Vimentin+) CTC-CTEC fusion cluster expressing both the epithelial marker EpCAM and the endothelial marker CD31, as well as large CTM with a series biomarkers expressing was also demonstrated in the present study, showing a significant interaction of tumor cells (TCs), endothelial cells (TECs), and mesenchymal cells (TMCs) during the process of EMT/EndoMT in peripheral circulation or implantation of cancer cells (30, 42).