Examination of aneuploid multinuclear clusters enriched from a breast cancer patient demonstrated a distinct CRC subtype with the unique phenotype of CD45-/EpCAM+/CD31+/Vimentin+ (Figure 3E), indicating the existence of rarely reported “aneuploid mesenchymal epithelial-endothelial fusion cluster” in cancer patients. The gene discussed is PECAM1; the disease is colorectal carcinoma.