Tumor biomarkers (CK18/PD-L1/EpCAM/AFP) and endothelial cell biomarker CD31 are heterogeneously localized in the cytoplasm, on the nuclear envelope, or in the nuclei, while stem cell biomarker CD133 and mesenchymal cell biomarker Vimentin mainly showed an intracellular distribution. The gene discussed is KRT18; the disease is neoplasm.