PTPRC and neoplasm: Future extensive investigation on the proliferation and differentiation of CRCs in either circulation or tumor microenvironment, what the clinical significance of CD45+ blood cells with aberrant phenotypic and karyotypic characterization, CTM or rare fusion clusters have, and establishment of standardization of cutoff thresholds for diagnosis or prognosis of specific diseases will shed light on a better understanding of the diverse categories of CRCs and subsequently benefit personalized clinical management for varieties of patients.