Furthermore, we found that the average combined NE score of tumors in either POU2F3 (median = 88) or YAP1 (median = 63) subtypes were dramatically lower than tumor in either ASCL1 (median = 165) or NEUROD1 (median = 156) subtypes, which was consistent with previous report (12, 15) and suggested that the degree of NE differentiation may contribute to the evolution of molecular subtypes. Here, YAP1 is linked to neoplasm.