As reported by Taofeek (18), we confirmed that molecular subtypes determined by IHC were an independent indicator for survival outcome in primary SCLC patients, and the best survival benefit of SCLC tumors had an YAP1 subtype, followed by POU2F3 and ASCL1 subtypes, which exhibited consistent tendency in mRNA and protein levels. The gene discussed is ASCL1; the disease is small cell lung carcinoma.