In the obesity subgroup, there was an increased proportion of individuals with higher BMI, HC, and fasting insulin and ACTH levels in the highest TSH quartile group (p=0.004 for BMI, p=0.045 for HC, p=0.045 for fasting insulin level, p < 0.001 for ACTH level). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.