Multivariable logistic regression indicated that systolic blood pressure, type of AF, previous coronary stent implantation, white blood cell count, hemoglobin, red cell distribution width, platelet count, uric acid, free fatty acid, N-terminal pro-B type natriuretic peptide, and left ventricular ejection fraction were independently related to big ET-1 ≥ 0.54 pmol/l (all p < 0.05) (Table 2). The gene discussed is EDN1; the disease is atrial fibrillation.