miR-181b in CRC has been reported to be an oncomiRNA and the probable mechanism could be that association with the mutation status of the p53 gene [45], Warburg effect promotion [46], cylindromatosis (CYLD) expression suppression, PDCD4 suppression [35],and the NF-κB signaling pathway [15] inhibition. The gene discussed is CYLD; the disease is colorectal carcinoma.