After the lasso machine learning on candidate 389 mRNA and 111 lncRNA, the mRNA panel (FAM72 C, ZFP36, GRASP, FOSB, SERPINE1, P2RX6), the lncRNA panel (AC104260.1, AC126177.4, LINC02511, DKFZp779M0652, AC025040.1), and the miRNA panel (hsa-mir-143 and hsa-mir-221) for Basal breast cancer were identified. The gene discussed is SERPINE1; the disease is breast cancer.