Four patients were immunocompromised, with one patient receiving bilateral lung transplantation for destructive pneumonophthisis, one patient receiving long-term corticosteroid therapy for nephrotic syndrome and hypoalbuminemia, one case of STAT3 hyper-IgE syndrome and one case of anti-IFN-γ autoantibody-associated immunodeficiency syndrome (Table 1). This evidence concerns the gene STAT3 and Hypoalbuminemia.