Another two cases of Talaromyces marneffei mixed infection were confirmed to have atypical types of immunodeficiency after the occurrence of Talaromyces marneffei infection, one with STAT3 hyper-IgE syndrome and the other with anti-IFN-γ autoantibody-associated immunodeficiency syndrome. The gene discussed is STAT3; the disease is immunodeficiency disease.