Furthermore, PredictProtein (PROFAcc) identified the 624–629 protein region of SAMD9L as a solvent-exposed region (Supplementary Fig. 6) and NetPhos 3.1 and NetworKIN algorithms predicted the residue Ser626 within SAMD9L to be potentially phosphorylated by protein kinase C (Supplementary Fig. 7), a kinase directly implicated in cerebellar neurodegeneration in the SCA 14 subtype.48 This evidence concerns the gene SAMD9L and autosomal dominant cerebellar ataxia.