Similar effects on zebrafish phenotype by overexpressing wild-type proteins, such as in our study, were previously described for other genes involved in neurodegenerative diseases such as SPG and neuropathy, ATL1 gene; ALS, SOD1 and TDP43 genes143–145; as well as with genes associated with ataxia including RNF170 and VLDLR. Here, TARDBP is linked to cerebellar ataxia.