Individuals with abnormal λ and CSF p-tau values showed a higher risk of progression to dementia, that is an OR of 6.5 (95% CI = 2.2–18.9) and an OR of 3.1 (95% CI = 1.0–9.4), respectively, however, this was accompanied with larger CIs and low accuracy values <0.5. Here, MAPT is linked to dementia.