In contrast, the MFI of IFN-γ and IL-2 was significantly higher in CD8+ T cells of SSc patients with anti-Scl-70 antibody than that in patients without anti-Scl-70 antibody (IFN-γ; 357.00 ± 43.6 vs 303.00 ± 38.70; p < 0.001 and IL-2; 356.60 ± 44.71 vs 314.30 ± 44.73; p < 0.01) (Figure 5). This evidence concerns the gene IFNG and systemic sclerosis.