Large-scale genome-wide association studies have successfully identified many AD-associated genetic variants, such as ATP8B1 rs2571244, DLGAP2 at chr8: 1316870 and ADAM17 rs142946965 (Dumitrescu et al., 2020; Hartl et al., 2020; Ouellette et al., 2020). The gene discussed is ADAM17; the disease is Alzheimer disease.