In addition, Sanchez-Mut et al. observed that promoter hypermethylation caused a reduced expression of DUSP22 in the hippocampus of AD patients, and DUSP22 depletion could inhibit tau Thr231 phosphorylation and activated CREB signal by increasing the phosphorylation of PKA thr197 (Sanchez-Mut et al., 2014). The gene discussed is MAPT; the disease is Alzheimer disease.