Decreased NPTX2 level has been reported to be associated with diverse neurological diseases, including Alzheimer’s disease, anxiety, vascular dementia, Parkinson’s disease and ischemia (Moran et al., 2008; Chang et al., 2018; Cai et al., 2019; Shao et al., 2020; Libiger et al., 2021). This evidence concerns the gene NPTX2 and early-onset autosomal dominant Alzheimer disease.