According to a previous study involving flavivirus infection (Schoggins, 2014), the mRNA levels of six key ISGs, i.e., IFITM1, IFITM3, OASL2, PKR, VIPERIN, and ISG15, were analyzed by real-time PCR in the spleen and liver. Here, EIF2AK2 is linked to Flavivirus Infections.