In particular, the aberration of some signaling cascades, among which the epidermal growth factor receptor (EGFR), Wnt/beta-catenin, transforming growth factor beta (TGF-β), PI3K-AKT-mTOR, Ras, and Stat, are associated with various HNSCC development mechanisms (Molinolo et al., 2009). The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.