BDNF and Salla disease: The major discoveries are that: (1) modafinil alleviates NLRs inflammasome-mediated pyroptosis in mice subjected to SD; (2) modafinil alleviates inflammation induced by neuronal pyroptosis in mice subjected to SD; (3) modafinil promotes BDNF activation in the hippocampi of mice subjected to SD, which is beneficial for synaptic plasticity; and (4) modafinil improves learning and memory in mice subjected to SD.