l-THP blocked TNF-α-induced adhesion of monocytes to human umbilical vein endothelial cells by inhibiting the production of both mRNA and protein levels of vascular cell adhesion molecule-1 (VCAM-1) along with the attenuation of TNF-α-stimulated NF-κB translocation in monocytes, highlighting its potential pharmacological action to intervene atherosclerosis [94]. The gene discussed is TNF; the disease is atherosclerosis.