In astrocytes, p53 regulated the expression of a variety of SASP factors (IL-1β, IL-6, and IL-8) (Turnquist et al., 2016), while another tumor suppressor gene Rb promoted the activation of the SASP (IL-6) in the mouse osteosarcoma model (Li and Zhang, 2017). This evidence concerns the gene IL6 and osteosarcoma.