Our recent study demonstrated that tumor suppressing subtransferable candidate 4 (TSSC4) is upregulated by EGFR activation in GBM cells and TSSC4 acts as a novel autophagy suppressor by interacting with LC3 (Chen et al., 2021), providing an example for linking EGFR signaling to autophagy proteins other than Beclin 1. This evidence concerns the gene EGFR and glioblastoma.