Kudou et al. (2019) found that TRPV2 regulates cancer progression by affecting WNT/β-catenin or basal cell carcinoma signaling, and that TRPV2 strong expression is associated with a worse prognosis in ESCC patients. In ESCC cells, TRPC6 can arrest the cell cycle in G2/M phase by inhibit elevation of [Ca2+] and activation of Cdc2 kinase, thereby inducing cell apoptosis (Zhang et al., 2013; Zhang et al., 2017). Lan et al. (2019) proved that TRPM8 regulated PD-L1 expression by calcineurin-NFATc3 pathway in esophageal cancer cells. The gene discussed is NFATC3; the disease is esophageal squamous cell carcinoma.