The expression of TRPM5, TRPM3, PLCB4, ITPR1, PTGER2, ADCY6, PRKACB, and PRKCG was obviously declined in ESCC tissues by comparing with that in normal tissues, whereas TRPV4, TRPV3, HTR2C, PLA2G4E, ASIC5, CALML3, CALML5, IL1RAP, MAPK12, and NGF expression were significantly increased. This evidence concerns the gene HTR2C and esophageal squamous cell carcinoma.