BECN1 and breast neoplasm: Beclin-1 expression inversely correlates with Akt and extracellular regulated kinase 1/2 (ERK) phosphorylation in human breast tumors through its Beclin-1-dependent regulation of insulin-like growth factor-1 (IGF-1) and EGF receptor trafficking (Rohatgi et al., 2015) (Figure 1).