miR-34a participates in a feedback loop in which interleukin-6 (IL-6) mediates the repression of miR-34a, leading to the activation of IL-6R and STAT3, which in turns maintains the repression of miR-34a that helps to support a mesenchymal pro-metastatic phenotype in colorectal cancer cells (Rokavec et al., 2014). The gene discussed is IL6; the disease is colorectal cancer.