Although under IVD degeneration conditions, some cytokines, including IL-17A, elevated VEGF, which then promoted angiogenesis and vasculogenesis in disc lesions to exacerbate IDD (Lee et al., 2011; Studer et al., 2011; Binch et al., 2014). The gene discussed is IL17A; the disease is intervertebral disk degenerative disorder.