NF-κB and MAPK pathways which IL-17A effected on, regulate pro-inflammatory mediators such as TNF-α, IL-1β or IL-6, as both pathways have been identified as master regulators of inflammation and catabolism in IDD and LDH (Sakai and Grad, 2015). The gene discussed is NFKB1; the disease is intervertebral disk degenerative disorder.