CDH2 and neoplasm: Blood vessels deficient in pericytes (e.g., tumor microvessels) exhibit poor blood flow, increased permeability, and an abnormal basement membrane (Jain 2005; Blaschuk and Devemy 2009; Li et al., 2019; Mrozik et al., 2020) making them particularly susceptible to disruption by N-cadherin antagonists (Blaschuk and Rowlands 2000, 2006).