FTH1 and hepatocellular carcinoma: Sun et al. (2016a) showed that it was FTH1, not FTL or TFR1, that was regulated by NRF2 in ferroptosis. FTH1 inhibited ferroptosis by storing and transporting Fe2+ in HCC cells. In addition, excess iron in the liver may play a role in carcinogenesis by promoting tumor growth and altering the immune system (Kowdley, 2004).