After intersecting genes in the yellow module of WGCNA with DEGs, we identified five myCAFs marker genes defined by previous single-cell sequencing (Elyada et al., 2019) that were significantly down-regulated in tumor tissues, including ACTA2, MYL9, TAGLN, TPM1, and TPM2 (Figures 1C,D). This evidence concerns the gene ACTA2 and neoplasm.