STAT3 and neoplasm: In addition, myCAFs could also affect several signaling pathways related to tumor cell stemness, such as the STAT3 (Wang et al., 2018), KRAS (Yoon et al., 2019), and Notch (Yang et al., 2020) signaling pathways, suggesting that the abundance of myCAFs may affect tumor stemness (Figures 5A,B).