Neutrophils expressing reverse migration markers (ICAMhi and CXCR1low) during the physiopathology of sepsis were found to present a pro-inflammatory phenotype, are highly active, have prolonged lifespan (Zhang et al., 2015; Ng et al., 2019), delayed apoptosis (Ng et al., 2019), and exhibit high production of superoxide (Ode et al., 2018), as well as high levels of inducible nitric oxide synthase (iNOS) and NETs (Hesse et al., 2004). The gene discussed is NOS2; the disease is Sepsis.