Hypercholesterolemia also fuels the process of neutrophil production in mice by regulating production of IL-23 by macrophages that leads to systemic release of granulocyte colony-stimulating factor (G-CSF) (Westerterp et al., 2012; Casanova-Acebes et al., 2018). This evidence concerns the gene CSF3 and familial hypercholesterolemia.