ADAM10 and neoplasm: In addition, A disintegrin and metalloproteinase 10 (ADAM10), a catalytically active member of the ADAM family of proteases, also known as “molecular scissors” (Tosetti et al., 2018), is involved in the cleavage of some NKG2D ligands in various types of cancer cells either in steady-state conditions or in response to a variety of stress stimuli, affecting the normal recognition of NKG2D receptors in tumor cells (Oh et al., 2020; Smith et al., 2020).