ITPR1 and cancer: Likewise, alterations in expression and activity levels of SERCA, PMCA, TRPM7, ORAI/STIM1-mediated SOCE, and IP3R isoforms have been demonstrated in several cancer cell types [detailed reviews can be found here (Marchi and Pinton, 2016; Raynal et al., 2016; Izquierdo-Torres et al., 2020)].