For example, the SERCA3 gene (ATP2A3) exhibits hypermethylation and decreased expression in colon cancer: patients with low expression levels of SERCA3 displayed an average survival of 16.6 months, whereas patients with high expression levels survived 26.7 months (Meneses-Morales et al., 2019). The gene discussed is ATP2A3; the disease is colonic neoplasm.